GENDI Consortium

The main objectives of the project are to find gene-diet interactions in the development of atherosclerosis and osteoporosis and to obtain new information on the mechanisms and congruencies in the etiology of these diseases.

The research expands from the Cardiovascular Risk in Young Finns Study.

More information about the GENDI Consortium: vera.mikkila@helsinki.fi

Imaging of fatty liver in YFS

Fatty liver is the first stage of nonalcoholic fatty liver disease, and it has been associated with cardiovascular risk markers, type 2 diabetes and insulin resistance. Liver was scanned in the YFS in 2011 from 2024 participants (age 34-49 years) with ultrasound and graded as normal liver, slightly fatty liver or obvious fatty liver. This project aims at studying the prevalence of fatty liver and at testing the metabolically healthy obesity hypothesis. Other aims are to study the roles of obesity, insulin resistance, lipid subclasses and hepatic steatosis in subclinical atherosclerosis. The extensive genetic data in the YFS enables us to replicate the findings of the published GWA studies to study the associations between the genetic variants and fatty liver, and to increase understanding about the effects of a genetic susceptibility to fatty liver on the pathophysiology of atherosclerosis.

More information about the imaging of fatty liver in the YFS: mervi.oikonen@utu.fi

Intergenerational transmission of socio-emotional well-being: A multidisciplinary study of offspring development across the lifecourse (MIND project)

Currently it is known that socio-emotional problems run in the same families across generations. Traditionally, it was thought that social phenomena transmit because of social learning, that is, children model their parents. However, newer techniques have shown that transmission may be related to changes in the brain or an individual's genetic expression. We will study whether socio-emotional problems transmit across generations and whether this transmission is modified by changes in neurobiology or genetic expression. We will examine these questions in unique datasets that include several measurements of the same individuals over development, as well as measurements of generations before and ahead. The study will bring totally new scientific perspectives on how human well-being develops. The results will lead to better understanding of human well-being and better justification for initiatives when planning early prevention to improve public health.

More information about the MIND project:
liisa.keltikangas-jarvinen@helsinki.fi
MIND.pdf

 

 

 

 

 

 

 

 

 

 

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